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Synthesis 2019; 51(07): 1595-1602
DOI: 10.1055/s-0037-1610355
DOI: 10.1055/s-0037-1610355
paper
An Efficient Catalytic Amidation of Esters Promoted by N-Heterocyclic Carbenes
The authors are grateful for financial support from the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, and the Students Innovation Program in Shanghai University of Engineering Science (cs1704005).Further Information
Publication History
Received: 23 August 2018
Accepted after revision: 13 November 2018
Publication Date:
19 December 2018 (online)
Abstract
An efficient NHC-catalyzed amidation between esters and amines or hydrazines is described. This strategy was tolerant for a wide scope of substrates, affording a series of amides (or hydrazides) in good to excellent yields (60–96%) under simple conditions. The approach was also used to synthesize the pharmaceutically relevant antidepressant moclobemide in 85% yield.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610355.
- Supporting Information
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