Electrophilic Sulfoximidations of Thiols by Hypervalent Iodine Reagents

Abstract

A new electrophilic sulfoximidation of thiols has been developed. Using sodium hydride as a base, the treatment of sulfoximidoyl-containing hypervalent iodine(III) reagents with thiols affords the corresponding N-sulfenylsulfoximines (N-thiosulfoximines) in good to excellent yields. A plausible mechanism is proposed.

Key words

sulfoximidation - thiol - N-sulfenylsulfoximine - hypervalent iodine reagents - ligand exchange

• References


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