Alkylpotassium-Catalyzed Benzylic C–H Alkylation of Alkylarenes with Alkenes

Io Sato; Yasuhiro Yamashita; Shū Kobayashi

doi:10.1055/s-0037-1610378

Synthesis, Inhaltsverzeichnis

CC BY-ND-NC 4.0 · Synthesis 2019; 51(01): 240-250
DOI: 10.1055/s-0037-1610378

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Alkylpotassium-Catalyzed Benzylic C–H Alkylation of Alkylarenes with Alkenes

Io Sato

,

Yasuhiro Yamashita*

Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan eMail: shu_kobayashi@chem.s.u-tokyo.ac.jp eMail: yyamashita@chem.s.u-tokyo.ac.jp

,

Shū Kobayashi *

Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan eMail: shu_kobayashi@chem.s.u-tokyo.ac.jp eMail: yyamashita@chem.s.u-tokyo.ac.jp

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Abstract

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Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue

Abstract

Catalytic benzylic C–H alkylation reactions of alkylarenes with alkenes such as β-substituted styrenes and vinylsilanes have been achieved by utilizing alkylpotassium as a catalyst. Various substituted toluene derivatives can be alkylated under mild reaction conditions to afford the desired functionalized hydrocarbons in moderate to high yields.

Key words

strong base - alkylarene - alkylation - alkylpotassium - alkene

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Referenzen

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