A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine
derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic
addition of tertiary enamides to imines has been developed. We have also demonstrated
a substrate engineering strategy to significantly improve the enantioselectivity of
asymmetric catalysis
Key words
tertiary enamides - 1,2,3,4-tetrahydropyridines - asymmetric catalysis - chiral phosphoric
acid - substrate engineering