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CC BY-ND-NC 4.0 · Synthesis 2019; 51(01): 146-160
DOI: 10.1055/s-0037-1610396
DOI: 10.1055/s-0037-1610396
short review
Twofold Ferrocene C–H Lithiations For One-Step Difunctionalizations
Université de Rennes 1.Weitere Informationen
Publikationsverlauf
Received: 29. Oktober 2018
Accepted: 05. November 2018
Publikationsdatum:
05. Dezember 2018 (online)
Abstract
For some aromatics, a twofold C–H deprotolithiation can be achieved, allowing these compounds to be subsequently difunctionalized in one step. This short review brings together examples in which ferrocenes are converted in this way.
1 Introduction
2 Bare Ferrocene
3 Ferrocenes Substituted by Alkyl or Silyl Groups
4 Ferrocenes Substituted by Aminoalkyls
5 Ferrocenes Substituted by Halogens or Oxygen-Based Groups
6 Ferrocenes Substituted by Alkoxyalkyls or Acetals
7 Ferrocenes Substituted by Sulfoxides
8 Ferrocenes Substituted by Oxazolines
9 Ferrocenes Substituted by Carboxamides
10 Conclusion
-
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For access to dilithium compounds using these methodologies, see:
For reviews on ferrocene functionalization including ferrocene deprotometalation, see:
For a synthesis of the dibromo product, see also:
See also: