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CC BY-ND-NC 4.0 · SynOpen 2018; 02(04): 0306-0311
DOI: 10.1055/s-0037-1610400
DOI: 10.1055/s-0037-1610400
paper
Natural Deep Eutectic Solvents as Sustainable Solvents for Suzuki–Miyaura Cross-Coupling Reactions Applied to Imidazo-Fused Heterocycles
Weitere Informationen
Publikationsverlauf
Received: 11. Oktober 2018
Accepted after revision: 02. November 2018
Publikationsdatum:
27. November 2018 (online)
Abstract
Herein, we present the first Suzuki–Miyaura cross-coupling in a sustainable natural deep eutectic solvent (NaDES) applied to biologically relevant imidazo-fused scaffolds imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine. The choline chloride/glycerol (1:2, mol/mol) NaDES allowed the functionalisation of diverse positions on the heterocycles with various boronic acids, by using 2.5 mol% of readily available Pd(OAc)2. Notably, the catalytic system proceeds without any ligands or additives, without protection from the atmosphere.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610332.
- Supporting Information
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