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Synthesis 2018; 50(20): 4104-4112
DOI: 10.1055/s-0037-1610540
DOI: 10.1055/s-0037-1610540
paper
Isocyanide-Based MCRs: Straightforward Access to Perfluroalkylated γ-Spiroiminolactones
The authors are grateful to the National Natural Science Foundation of China (NSFC) (Grant Nos. 21672138, 21542005, 21272152) for financial support.Further Information
Publication History
Received: 07 May 2018
Accepted after revision: 06 June 2018
Publication Date:
16 July 2018 (online)
![](https://www.thieme-connect.de/media/synthesis/201820/lookinside/thumbnails/ss-2018-h0315-op_10-1055_s-0037-1610540-1.jpg)
Abstract
A variety of perfluoroalkyl-substituted γ-spiroiminolactones have been synthesized via a one-pot, three-component cascade reaction in which isocyanides, methyl perfluoroalk-2-ynoates and 1,2-diketones undergo highly regioselective Michael addition, nucleophilic addition and cyclization. This reaction has the advantages of good to excellent chemical yields, operationally simple procedure, and short reaction times.
Key words
spiroiminolactones - perfluoroalkyl-substituted - isocyanide - multicomponent reaction - methyl perfluoroalk-2-ynoateSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609549.
- Supporting Information
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For selected recent examples for isocyanide-based iminolactonizations, see: