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Synthesis 2019; 51(02): 508-515
DOI: 10.1055/s-0037-1610629
DOI: 10.1055/s-0037-1610629
paper
Catalyst-Free Photodriven Reduction of α-Haloketones with Hantzsch Ester
The authors are grateful to the National Natural Science Foundation of China (No. 21572118 & No. 21572080), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), and Jiangsu University (No. 10JDG042 and No. 14JDG018) for their generous support.
Further Information
Publication History
Received: 20 May 2018
Accepted after revision: 04 August 2018
Publication Date:
29 August 2018 (online)
Dedicated to Professor Xiyan Lu on the occasion of his 90th birthday.
Abstract
Catalyst-free dehalogenation of α-haloketones under visible light irradiation is studied. The reactions were carried out in common organic solvent. The outcomes of dechlorination are excellent in yields up to 92%, and it is also applicable to bromides, which give even higher yields. The reaction is tolerable to a broad spectrum of substrates, especially to aromatic ketones, including various aryl and hetaryl groups. There are two examples of aliphatic ketones presented in the paper, although their reactivities are not as high as that of the aromatic ketones.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610629.
- Supporting Information
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