Morpholin-2-one Derivatives via Intramolecular Acid-Catalyzed Hydroamination

Abstract

Substituted morpholin-2-one derivatives were readily obtained in two steps starting from commercially available N-protected amino acids. In a metal-free and practical method, a catalytic amount of trifluoromethanesulfonic acid was sufficient to generate morpholinones under mild reaction conditions in an intramolecular hydroamination reaction in good to excellent yields.

Key words

amino acids - cyclization - hydroamination - morpholinone - trifluoromethanesulfonic acid

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