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Synthesis 2019; 51(07): 1643-1648
DOI: 10.1055/s-0037-1610674
DOI: 10.1055/s-0037-1610674
paper
Morpholin-2-one Derivatives via Intramolecular Acid-Catalyzed Hydroamination
Further Information
Publication History
Received: 06 September 2018
Accepted after revision: 06 November 2018
Publication Date:
07 January 2019 (online)
Abstract
Substituted morpholin-2-one derivatives were readily obtained in two steps starting from commercially available N-protected amino acids. In a metal-free and practical method, a catalytic amount of trifluoromethanesulfonic acid was sufficient to generate morpholinones under mild reaction conditions in an intramolecular hydroamination reaction in good to excellent yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610674.
- Supporting Information
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