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Synthesis 2020; 52(09): 1417-1424
DOI: 10.1055/s-0037-1610739
DOI: 10.1055/s-0037-1610739
paper
One-Pot Copper-Catalyzed Three-Component Reaction of Sulfonyl Azides, Alkynes, and Allylamines To Access 2,3-Dihydro-1H-imidazo[1,2-a]indoles
This work was supported by the National Science Foundation of China (Grant / Award Number: 'Nos. 21772176 and 21372201').Further Information
Publication History
Received: 02 September 2019
Accepted after revision: 26 November 2019
Publication Date:
05 February 2020 (online)
Abstract
A copper-catalyzed multicomponent reaction of sulfonyl azides, alkynes, and allylamines affording 2,3-dihydro-1H-imidazo-[1,2-a]indoles in moderate yields is reported. Four C–N bonds are constructed by way of azide-alkyne cycloaddition (CuAAC) and double Ullmann-type coupling reactions in a one-pot process.
Key words
multicomponent reaction - copper catalysis - azide-alkyne cycloaddition - Ullmann coupling reaction - 2,3-dihydro-1H-imidazo[1,2-a]indolesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610739.
- Supporting Information
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