One-Pot Copper-Catalyzed Three-Component Reaction of Sulfonyl Azides, Alkynes, and Allylamines To Access 2,3-Dihydro-1H-imi­dazo[1,2-a]indoles

Hongwei Jin; Daohong Liu; Bingwei Zhou; Yunkui Liu

doi:10.1055/s-0037-1610739

Synthesis, Table of Contents

Synthesis 2020; 52(09): 1417-1424
DOI: 10.1055/s-0037-1610739

paper

One-Pot Copper-Catalyzed Three-Component Reaction of Sulfonyl Azides, Alkynes, and Allylamines To Access 2,3-Dihydro-1H-imidazo[1,2-a]indoles

Hongwei Jin

,

Daohong Liu

,

Bingwei Zhou∗

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China Email: zhoubw@zjut.edu.cn Email: ykuiliu@zjut.edu.cn

,

Yunkui Liu∗

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China Email: zhoubw@zjut.edu.cn Email: ykuiliu@zjut.edu.cn

› Author Affiliations

Abstract

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Abstract

A copper-catalyzed multicomponent reaction of sulfonyl azides, alkynes, and allylamines affording 2,3-dihydro-1H-imidazo-[1,2-a]indoles in moderate yields is reported. Four C–N bonds are constructed by way of azide-alkyne cycloaddition (CuAAC) and double Ullmann-type coupling reactions in a one-pot process.

Key words

multicomponent reaction - copper catalysis - azide-alkyne cycloaddition - Ullmann coupling reaction - 2,3-dihydro-1H-imidazo[1,2-a]indoles

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References

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Supplementary Material

Supporting Information

One-Pot Copper-Catalyzed Three-Component Reaction of Sulfonyl Azides, Alkynes, and Allylamines To Access 2,3-Dihydro-1H-imi­dazo[1,2-a]indoles

One-Pot Copper-Catalyzed Three-Component Reaction of Sulfonyl Azides, Alkynes, and Allylamines To Access 2,3-Dihydro-1H-imidazo[1,2-a]indoles