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Synthesis 2019; 51(02): 522-529
DOI: 10.1055/s-0037-1610907
DOI: 10.1055/s-0037-1610907
paper
Visible-Light Photoredox-Catalyzed Cascade Reaction for the Synthesis of Pyrrolo[2,1-a]isoquinoline-Substituted Phosphonates
We are grateful to the NSFC (No. 21342004 and 51573066), Program of Introducing Talents of Discipline to Universities of China (111 Program, B17019) and the Syngenta Ph.D. (postgraduate) program for support of this research.Further Information
Publication History
Received: 06 August 2018
Accepted after revision: 21 August 2018
Publication Date:
17 September 2018 (online)


Abstract
A visible-light photoredox-catalyzed oxidation/[3+2] cycloaddition/oxidative aromatization cascade reaction of [(3,4-dihydroisoquinolin-2(1H)-yl)methyl]phosphonates and activated olefins or alkynes for the efficient synthesis of potentially biological active pyrrolo[2,1-a]isoquinoline-substituted phosphonates was developed. This transformation features mild reaction conditions (i.e., visible light irradiation, room temperature), molecular oxygen (O2) as a green oxidant, simple ‘one-pot’ operation.
Key words
visible light catalysis - [3+2] cycloaddition - pyrrolo[2,1-a]isoquinoline - phosphonate - cascade reactionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610907.
- Supporting Information