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Synthesis 2019; 51(13): 2713-2719
DOI: 10.1055/s-0037-1611533
DOI: 10.1055/s-0037-1611533
special topic
Enantioselective Synthesis of 2-Substituted Pyrrolidines via Intramolecular Reductive Amination
Financial support from the National Natural Science Foundation of China (21772155, 21402155 and 21602172) is gratefully acknowledged.Weitere Informationen
Publikationsverlauf
Received: 19.03.2109
Accepted after revision: 12. April 2019
Publikationsdatum:
07. Mai 2019 (online)
![](https://www.thieme-connect.de/media/synthesis/201913/lookinside/thumbnails/ss-2019-c0051-st_10-1055_s-0037-1611533-1.jpg)
Published as part of the Special Topic Amination Reactions in Organic Synthesis
Abstract
Catalyzed by the complex generated in situ from iridium and the chiral ferrocene ligand, tert-butyl (4-oxo-4-arylbutyl)carbamate substrates were deprotected and then reductively cyclised to form 2-substituted arylpyrrolidines in a one-pot manner, in which the intramolecular reductive amination was the key step. A range of chiral 2-substituted arylpyrrolidines were synthesised in up to 98% yield and 92% ee.
Key words
asymmetric catalysis - intramolecular reductive amination - iridium - chiral ligand - arylpyrrolidineSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611533.
- Supporting Information
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