Synthesis 2019; 51(17): 3336-3344
DOI: 10.1055/s-0037-1611536
paper
© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted CuCl-Catalyzed Three-Component Reactions of Alkynes, Aldehydes, and Amino Alcohols

Xiang Li
,
Ning Chen  *
State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. of China   Email: chenning@mail.buct.edu.cn   Email: jxxu@mail.buct.edu.cn
,
Jiaxi Xu*
State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. of China   Email: chenning@mail.buct.edu.cn   Email: jxxu@mail.buct.edu.cn
› Author Affiliations
This work was supported by the National Natural Science Foundation of China (Grant Nos. 21702014, 21572017 and 21772010), the National Basic Research Program of China (Grant No. 2013CB328905) and the Fundamental Research Funds for the Central Universities (XK1802-6).
Further Information

Publication History

Received: 11 February 2019

Accepted after revision: 12 April 2019

Publication Date:
08 May 2019 (online)


Abstract

A microwave (MW)-assisted three-component coupling of amino alcohols, aldehydes, and alkynes is developed under catalysis by CuCl. Compared with thermal conditions, MW irradiation greatly increases the reaction efficiency. The reactions of various primary N-alkyl/arylamino alcohols, aliphatic/aromatic aldehydes, and alkynes are systematically investigated, affording the desired products in moderate to good yields. Notably, acetylene is also an effective reactant under the current MW-assisted conditions.

Supporting Information