Chemo- and Regioselective Palladium(II)-Catalyzed Aminoaryl­ation of N-Allylureas Providing 4-Arylmethyl Imidazolidinones

Sabrina Giofrè; Egle M. Beccalli; Francesca Foschi; Concetta La Rosa; Leonardo Lo Presti; Michael S. Christodoulou

doi:10.1055/s-0037-1611539

Synthesis, Inhaltsverzeichnis

Synthesis 2019; 51(18): 3462-3470
DOI: 10.1055/s-0037-1611539

paper

Chemo- and Regioselective Palladium(II)-Catalyzed Aminoarylation of N-Allylureas Providing 4-Arylmethyl Imidazolidinones

Sabrina Giofrè

^aDISFARM, Sezione di Chimica Generale e Organica “A. Marchesini”, Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy eMail: egle.beccalli@unimi.it

,

Egle M. Beccalli *

^aDISFARM, Sezione di Chimica Generale e Organica “A. Marchesini”, Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy eMail: egle.beccalli@unimi.it

,

Francesca Foschi

^bDipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, 20133 Milano, Italy

,

Concetta La Rosa

^aDISFARM, Sezione di Chimica Generale e Organica “A. Marchesini”, Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy eMail: egle.beccalli@unimi.it

,

Leonardo Lo Presti

^bDipartimento di Chimica, Università degli Studi di Milano, via Golgi 19, 20133 Milano, Italy

,

Michael S. Christodoulou

^aDISFARM, Sezione di Chimica Generale e Organica “A. Marchesini”, Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy eMail: egle.beccalli@unimi.it

› Institutsangaben

Abstract

Alle Artikel dieser Rubrik

Abstract

The aminoarylation reaction of N-allylureas under oxidative palladium catalysis, in the absence of ligands and by using inexpensive H₂O₂ as the sole oxidant, occurs in a chemo- and regioselective fashion. This intramolecular process takes place via a 5-exo-trig cyclization, and represents an easy approach to 4-arylmethyl imidazolidinones.

Key words

palladium catalysis - aminoarylation - hydrogen peroxide - imidazolidinones - ureas - domino reaction

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Supporting Information

Chemo- and Regioselective Palladium(II)-Catalyzed Aminoaryl­ation of N-Allylureas Providing 4-Arylmethyl Imidazolidinones

Chemo- and Regioselective Palladium(II)-Catalyzed Aminoarylation of N-Allylureas Providing 4-Arylmethyl Imidazolidinones