Recent Advances in the Application of Ring-Closing Metathesis for the Synthesis of Unsaturated Nitrogen Heterocycles

Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue

Abstract

This short review summarizes recent advances relating to the application of ring-closing olefin-olefin and carbonyl-olefin metathesis reactions towards the synthesis of unsaturated five- and six-membered nitrogen heterocycles. These developments include catalyst modifications and reaction designs that will enable access to more complex nitrogen heterocycles.

1 Introduction

2 Expansion of Ring-Closing Metathesis Methods

3 Evaluation of Catalyst Design

4 Indenylidene Catalysts

5 Unsymmetrical N-Heterocyclic Carbene Ligands

6 Carbonyl-Olefin Metathesis

7 Conclusions

Key words

RCM - carbonyl-olefin metathesis - nitrogen heterocycles - catalyst design - ruthenium - Lewis acid catalysis

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