Nucleophilic Trifluoromethylation Reactions Involving Copper(I) Species: From Organometallic Insights to Scope

^§These authors contributed equally to this work.

Published as part of the Bürgenstock Special Section 2018 Future Stars in Organic Chemistry

Abstract

Over the last decades, trifluoromethyl copper(I) complexes have played a key role as reactive species in C–CF₃ bond-forming reactions. This Short Review not only covers selected examples of relevant copper-mediated or catalyzed nucleophilic trifluoromethylation reactions, which is one of the most active fields in organic synthesis, but also provides a comprehensive picture of the real behavior of these copper species, including ubiquitous cuprates, in the reaction media.

1 Introduction

2 Historical Perspective of the Identification of Relevant Trifluoro-

methyl Copper(I) Species

3 In Situ Generation of Active Trifluoromethyl Copper(I) Species

4 Well-Defined Active Trifluoromethyl Copper(I) Complexes

5 Recent Advances on the Performance of Trifluoromethylation

Protocols

6 Conclusions

Key words

trifluoromethylation - copper - ate-type complexes - catalysis - organometallic chemistry

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