Synthetic Utility of One-Pot Chemoenzymatic Reaction Sequences

Tyler J. Doyon; Alison R. H. Narayan

doi:10.1055/s-0037-1611848

Synlett, Table of Contents

Synlett 2020; 31(03): 230-236
DOI: 10.1055/s-0037-1611848

cluster

Synthetic Utility of One-Pot Chemoenzymatic Reaction Sequences

Tyler J. Doyon

^aLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA

^bProgram in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, USA

,

Alison R. H. Narayan *

^aLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA

^bProgram in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, USA

^cDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA Email: arhardin@umich.edu

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Abstract

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Published as part of the Cluster Biocatalysis

Abstract

In recent years, there has been a rapid and sustained increase in the development and use of one-pot chemoenzymatic reaction processes for the efficient synthesis of high-value molecules. This strategy can provide a number of advantages over traditional synthetic methods, including high levels of selectivity in reactions, mild and sustainable reaction conditions, and the ability to rapidly build molecular complexity in a single reaction vessel. Here, we present several examples of chemoenzymatic one-pot reaction sequences that demonstrate the diversity of transformations that can be incorporated in these processes.

Key words

chemoenzymatic - biocatalysis - one-pot process

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References

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