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DOI: 10.1055/s-0037-1611870
A Concise Total Synthesis of (±)-Camptothecin
Publikationsverlauf
Received: 16. April 2019
Accepted after revision: 31. Mai 2019
Publikationsdatum:
26. Juni 2019 (online)
Abstract
A total synthesis of racemic camptothecin, characterized by a concise construction of the ring systems and easy functional group transformation, is described. A domino reaction consisting of a Heck reaction and an aza-intramolecular Michael addition to form the C ring serves as the first key step in the synthesis. The D ring was constructed by a simple Wittig–Horner reaction followed by removal of the protective groups. Hydroxymethylation, demethylation, and lactone formation reactions were performed in one-pot to construct the E ring under hydrobromic acid conditions. This work provides an efficient scheme for further synthetic exploration of camptothecin and its analogues.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611870.
- Supporting Information
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