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Synlett 2019; 30(13): 1597-1601
DOI: 10.1055/s-0037-1611881
DOI: 10.1055/s-0037-1611881
letter
Iron-Catalyzed Direct Transformation of Benzylic Amines into Carbonyl Compounds in Water
This research was partially supported by the Asahi Glass Foundation, and Yamagata University Gender Equality Office.Weitere Informationen
Publikationsverlauf
Received: 18. Mai 2019
Accepted after revision: 17. Juni 2019
Publikationsdatum:
12. Juli 2019 (online)
Abstract
Fe-catalyzed direct transformation of benzylic amines into carbonyl compounds was performed in H2O. The reaction of benzylic amines with formaldehyde in the presence of FeCl3·6H2O in H2O afforded the corresponding carbonyl compounds (80 °C to reflux conditions; 14 examples, up to 94% yield). O18-labeling experiments indicated that the O atom in the generated carbonyl is derived from H2O.
Key words
direct transformation - benzylic amines - carbonyl compounds - iron catalysis - formaldehydeSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611881.
- Supporting Information
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References and Notes
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