Recent Progress in the Copper-Catalyzed Cascade Cyclization Involving Intramolecular Hydroamination of Terminal Alkynes

‡ These authors contributed equally to this work.

Abstract

Transition-metal-catalyzed cascade cyclization initiated by intramolecular alkyne hydroamination has received considerable attention over the past decade and has been widely used in the rapid construction of a diverse array of valuable complex N-heterocycles. Recent progress in this area is reviewed with an emphasis on the cheap and environmentally benign copper-catalyzed cascade cyclization of terminal alkynes.

Key words

copper catalysis - hydroamination - alkynes - cascade reactions - cyclization - heterocycles

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