N-Alkynyl Pyrrole Based Total Synthesis of Shensongine A

Abstract

A copper-catalyzed N-alkynylation of pyrrole and a gold-catalyzed spiroketalization were key steps in the total synthesis of the pyrrole spiroketal alkaloid shensongine A. The preparation of this alkaloid is concise and amenable to the rapid synthesis of a diverse library of compounds.

Key words

cross-coupling - alkynes - nitrogen heterocycles - spiroketalization - shensongine A - pyrrole spiroketal alkaloids - total synthesis

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