Synthesis 2019; 51(20): 3865-3874
DOI: 10.1055/s-0037-1611908
paper
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed and Quinazoline-Directed C–H Selective Acetoxylation of 2-Arylquinazolines

Song Wei
a   Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China   Email: yypeng@jxnu.edu.cn   Email: yiyuanpeng@yahoo.com
,
Banlai Ouyang
a   Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China   Email: yypeng@jxnu.edu.cn   Email: yiyuanpeng@yahoo.com
b   Department of Chemistry, Nanchang Normal University, Nanchang, Jiangxi 330032, P. R. of China
,
Zhihong Deng
a   Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China   Email: yypeng@jxnu.edu.cn   Email: yiyuanpeng@yahoo.com
,
Qin Yang
a   Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China   Email: yypeng@jxnu.edu.cn   Email: yiyuanpeng@yahoo.com
,
Yiyuan Peng
a   Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China   Email: yypeng@jxnu.edu.cn   Email: yiyuanpeng@yahoo.com
› Author Affiliations
We are grateful to the National Natural Science Foundation of China (grant no. 21762020), Jiangxi Provincial Department of Science and Technology (for Jiangxi’s Key Laboratory of Green Chemistry, and no. 20171BAB203006), and the Science Foundation of Education Department of Jiangxi Province (grant no. GJJ10386 and GJJ12616) for their financial support.
Further Information

Publication History

Received: 20 May 2019

Accepted after revision: 24 July 2019

Publication Date:
08 August 2019 (online)


Abstract

A series of acetoxylated 2-arylquinazolines have been successfully synthesized via the Pd-catalyzed and quinazoline-directed C–H activation/acetoxylation of the corresponding 2-arylquinazolines with iodobenzene diacetate in AcOH/Ac2O.

Supporting Information