Palladium-Catalyzed and Quinazoline-Directed C–H Selective Acetoxylation of 2-Arylquinazolines

Song Wei; Banlai Ouyang; Zhihong Deng; Qin Yang; Yiyuan Peng

doi:10.1055/s-0037-1611908

Synthesis, Table of Contents

Synthesis 2019; 51(20): 3865-3874
DOI: 10.1055/s-0037-1611908

paper

Palladium-Catalyzed and Quinazoline-Directed C–H Selective Acetoxylation of 2-Arylquinazolines

Song Wei

^aKey Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China Email: yypeng@jxnu.edu.cn Email: yiyuanpeng@yahoo.com

,

Banlai Ouyang

^aKey Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China Email: yypeng@jxnu.edu.cn Email: yiyuanpeng@yahoo.com

^bDepartment of Chemistry, Nanchang Normal University, Nanchang, Jiangxi 330032, P. R. of China

,

Zhihong Deng

^aKey Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China Email: yypeng@jxnu.edu.cn Email: yiyuanpeng@yahoo.com

,

Qin Yang

^aKey Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China Email: yypeng@jxnu.edu.cn Email: yiyuanpeng@yahoo.com

,

Yiyuan Peng ∗

^aKey Laboratory of Small Functional Organic Molecule, Ministry of Education and Key Laboratory of Green Chemistry, Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China Email: yypeng@jxnu.edu.cn Email: yiyuanpeng@yahoo.com

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Abstract

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Abstract

A series of acetoxylated 2-arylquinazolines have been successfully synthesized via the Pd-catalyzed and quinazoline-directed C–H activation/acetoxylation of the corresponding 2-arylquinazolines with iodobenzene diacetate in AcOH/Ac₂O.

Keywords

2-arylquinazoline - acetoxylation - transition-metal catalysis - C–H activation - iodobenzene diacetate

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References

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