Copper-Catalyzed Decarboxylative N-Arylation of Indole-2-carboxylic Acids

Yan Zhang; Zhe-Yao Hu; Xin-Chang Li; Xun-Xiang Guo

doi:10.1055/s-0037-1611946

Synthesis, Inhaltsverzeichnis

Synthesis 2019; 51(08): 1803-1808
DOI: 10.1055/s-0037-1611946

paper

Copper-Catalyzed Decarboxylative N-Arylation of Indole-2-carboxylic Acids

Yan Zhang

^aKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, P. R. of China eMail: xunxiang_guo@sjtu.edu.cn

,

Zhe-Yao Hu

^aKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, P. R. of China eMail: xunxiang_guo@sjtu.edu.cn

,

Xin-Chang Li

^aKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, P. R. of China eMail: xunxiang_guo@sjtu.edu.cn

,

Xun-Xiang Guo*

^aKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, P. R. of China eMail: xunxiang_guo@sjtu.edu.cn

^bKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 311121, P. R. of China

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Abstract

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Abstract

A novel decarboxylative N-arylation of indole-2-carboxylic acids with aryl halides is developed. The reaction proceeds efficiently in the presence of Cu₂O as the catalyst to give the corresponding N-aryl indoles in high yields. This synthetic method shows good functional group tolerance and offers an alternative route to construct N-aryl indoles.

Key words

indole-2-carboxylic acids - N-arylation - copper - decarboxylation - synthetic methods

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Referenzen

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