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Synthesis 2019; 51(10): 2171-2182
DOI: 10.1055/s-0037-1612216
DOI: 10.1055/s-0037-1612216
paper
Copper-Catalyzed N-Arylation of Sulfoximines with Arylboronic Acids under Mild Conditions
J.K. gratefully acknowledges DST-India (DST/INT/MPG/P-09/2016) and Max-Planck Society, Germany for financial support through Indo-Max Planck partner group project. S.G. and S.B. acknowledge IIT (BHU) for a research fellowship.Further Information
Publication History
Received: 07 December 2018
Accepted after revision: 16 January 2019
Publication Date:
19 February 2019 (online)
Abstract
N-Arylation of sulfoximines with different arylboronic acids, including sterically hindered boronic acids, is achieved using copper(I) iodide and 4-DMAP at room temperature. Moreover, N-arylation of biologically relevant l-methionine sulfoximine is demonstrated for the first time. All these reactions provided the desired products in excellent yields within a short span of time. The optimized reaction conditions are well suited to the task of N-vinylation of sulfoximine with trans-2-phenylvinylboronic acid.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1612216.
- Supporting Information
- CIF File
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