Synthesis, Table of Contents Synthesis 2019; 51(10): 2171-2182DOI: 10.1055/s-0037-1612216 paper © Georg Thieme Verlag Stuttgart · New York Copper-Catalyzed N-Arylation of Sulfoximines with Arylboronic Acids under Mild Conditions Surabhi Gupta a Department of Chemistry, Indian Institute of Technology (BHU), 221005 Varanasi, Uttar Pradesh, India Email: jeyakumar.chy@iitbhu.ac.in , Siddharth Baranwal a Department of Chemistry, Indian Institute of Technology (BHU), 221005 Varanasi, Uttar Pradesh, India Email: jeyakumar.chy@iitbhu.ac.in , Nalluchamy Muniyappan b Department of Chemistry, Pondicherry University, 605014 Pondicherry, India , Shahulhameed Sabiah b Department of Chemistry, Pondicherry University, 605014 Pondicherry, India , Jeyakumar Kandasamy * a Department of Chemistry, Indian Institute of Technology (BHU), 221005 Varanasi, Uttar Pradesh, India Email: jeyakumar.chy@iitbhu.ac.in › Author Affiliations Recommend Article Abstract All articles of this category Abstract N-Arylation of sulfoximines with different arylboronic acids, including sterically hindered boronic acids, is achieved using copper(I) iodide and 4-DMAP at room temperature. Moreover, N-arylation of biologically relevant l-methionine sulfoximine is demonstrated for the first time. All these reactions provided the desired products in excellent yields within a short span of time. The optimized reaction conditions are well suited to the task of N-vinylation of sulfoximine with trans-2-phenylvinylboronic acid. Key words Key wordsarylation - boronic acid - sulfoximine - catalysis - copper Full Text References References 1a Reggelin M, Zur C. Synthesis 2000; 1 1b Lucking U. Angew. Chem. Int. Ed. 2013; 52: 9399 1c Frings M, Bolm C, Blum A, Gnamm C. Eur. J. Med. Chem. 2017; 126: 225 1d Bizet V, Kowalczyk R, Bolm C. Chem. Soc. Rev. 2014; 43: 2426 2a Bolm C. Sulfoximines as Ligands in Asymmetric Metal Catalysis. In Asymmetric Synthesis with Chemical and Biological Methods. Enders D, Jaeger K.-E. Wiley-VCH; Weinheim: 2007 2b Remy P, Langner M, Bolm C. Org. Lett. 2006; 8: 1209 2c Langner M, Bolm C. Angew. Chem. Int. 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