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Synthesis 2019; 51(10): 2207-2213
DOI: 10.1055/s-0037-1612248
DOI: 10.1055/s-0037-1612248
paper
A Free-Radical and Protecting-Group-Free Approach to (–)-Boschnialactone and γ-Lycorane
Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (DGAPA-UNAM) for project number IN205318 and for a postdoctoral fellowship for A.S.-E. Consejo Nacional de Ciencia y Tecnología (CONACYT) for grants numbers 767928 (A.B.-A.) and 620665 (V.E.G.-A.).Further Information
Publication History
Received: 14 December 2018
Accepted after revision: 16 January 2019
Publication Date:
27 February 2019 (online)
◊ Contributed equally to this work
Abstract
The protecting-group-free (PGF) and free-radical-based synthesis of two structurally different natural products, (–)-boschnialactone and γ-lycorane, is reported. The key step in both syntheses is a radical–ionic sequence for construction of the principal structure (a six-membered lactone and a 1,4-dicarbonyl compound, respectively), allowing short and rapid access to these natural products through a PGF route.
Key words
radicals - protecting-group-free synthesis - atom-transfer radical addition - ATRA - boschnialactone - lycoraneSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1612248.
- Supporting Information
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