The association of complement C3 genotype with coronary artery disease, markers of the metabolic syndrome and C3 plasma levels

Ramzi A. Ajjan; Peter J. Grant; Timothy S. Futers; Jane M. Brown; Angela M. Carter

doi:10.1055/s-0037-1612652

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2006; 95(02): 393-395
DOI: 10.1055/s-0037-1612652

Letters to the Editor

Schattauer GmbH

The association of complement C3 genotype with coronary artery disease, markers of the metabolic syndrome and C3 plasma levels

Ramzi A. Ajjan

¹Academic Unit of Molecular Vascular Medicine, Leeds Institute of Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, United Kingdom

,

Peter J. Grant

¹Academic Unit of Molecular Vascular Medicine, Leeds Institute of Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, United Kingdom

,

Timothy S. Futers

¹Academic Unit of Molecular Vascular Medicine, Leeds Institute of Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, United Kingdom

,

Jane M. Brown

¹Academic Unit of Molecular Vascular Medicine, Leeds Institute of Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, United Kingdom

,

Angela M. Carter

¹Academic Unit of Molecular Vascular Medicine, Leeds Institute of Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, United Kingdom

References
1 Hansson GK, Libby P, Schonbeck U. et al. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res 2002; 91: 281-91.
2 Muscari A, Bozzoli C, Puddu GM. et al. Association of serum C3 levels with the risk of myocardial infarction. Am J Med 1995; 98: 357-64.
3 Ajjan RA, Grant PG, Futers TS. et al. Complement C3 and C-reactive protein levels in patients with stable coronary artery disease. Thromb Haemost 2005; 94: 1048-53.
4 Botto M, Fong KY, So AK. et al. Molecular basis of polymorphisms of human complement component C3. J Exp Med 1990; 172: 1011-7.
5 Csaszar A, Duba J, Melegh B. et al. Increased frequency of the C3*F allele and the Leiden mutation of coagulation factor V in patients with severe coronary heart disease who survived myocardial infarction. Exp Clin Immunogenet 2001; 18: 206-12.
6 Kristensen BO, Petersen GB. Association between coronary heart disease and the C3F-gene in essential hypertension. Circulation 1978; 58: 622-5.
7 Krantz S, Stelter F, Lober M. et al. Complement component 3 (C3) genetics and diabetes mellitus. Biomed Biochim Acta 1990; 49: 1237-41.
8 Szeplaki G, Prohaszka Z, Duba J. et al. Association of high serum concentration of the third component of complement (C3) with pre-existing severe coronary artery disease and new vascular events in women. Atherosclerosis 2004; 177: 383-9.
9 Muscari A, Massarelli G, Bastagli L. et al. Relationship of serum C3 to fasting insulin, risk factors and previous ischaemic events in middle-aged men. Eur Heart J 2000; 21: 1081-90.