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Thromb Haemost 2001; 85(01): 63-66
DOI: 10.1055/s-0037-1612905
Review Article
Schattauer GmbH

High Levels of Adhesion Molecules Are Associated with Impaired Endothelium-dependent Vasodilation in Patients with Peripheral Arterial Disease

Gregorio Brevetti
1   Departments of Medicine and Laboratory Medicine, University Federico II, Napoli, Italy
,
Vincenzo D. Martone
1   Departments of Medicine and Laboratory Medicine, University Federico II, Napoli, Italy
,
Tiziana de Cristofaro
2   Departments of Laboratory Medicine, University Federico II, Napoli, Italy
,
Salvatore Corrado
1   Departments of Medicine and Laboratory Medicine, University Federico II, Napoli, Italy
,
Antonio Silvestro
1   Departments of Medicine and Laboratory Medicine, University Federico II, Napoli, Italy
,
Anna Maria Di Donato
1   Departments of Medicine and Laboratory Medicine, University Federico II, Napoli, Italy
,
Roxana Bucur
1   Departments of Medicine and Laboratory Medicine, University Federico II, Napoli, Italy
,
Francesco Scopacasa
2   Departments of Laboratory Medicine, University Federico II, Napoli, Italy
› Author Affiliations
Further Information

Publication History

Received 24 December 1999

Accepted after resubmission 07 August 2000

Publication Date:
08 December 2017 (online)

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Summary

Soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cellular adhesion molecule-1 (sVCAM-1) were measured alongside flow-mediated vasodilation (FMD) in 34 patients with intermittent claudication and 14 control subjects. Patients with plasma sICAM-1 >253 ng/mL (median value) showed lower FMD than those with sICAM-1 <253 ng/mL (5.6 ± 1.8% vs 9.6 ± 4.2%, p <0.01). Similarly, in the 17 patients with plasma sVCAM-1 >414 ng/mL, FMD was lower than in the remaining 17 patients (6.1 ± 1.9% vs 9.2 ± 4.5%, p <0.05). Additionally, when endothelial dysfunction was defined as FMD ≤5.5%, patients with FMD below this value had higher plasma concentrations of sICAM-1 and sVCAM-1 than those with FMD >5.5%. Therefore, our findings indicate a close association between elevated plasma levels of adhesion molecules and endothelial dysfunction. As impaired endothelial function is one of the first steps in atherogenesis, our findings have clinical relevance since they serve as the basis for further evaluation of sICAM-1 and sVCAM-1 as potential plasma markers for progression of atherosclerosis in a population at high risk.

Keywords

Adhesion molecules - flow-mediated dilation - endothelial dysfunction - intermittent claudication - peripheral arterial disease
 

  • References

  • 1 McDaniel MD, Cronewett JL. Basic data related to the natural history of intermittent claudication. Ann Vasc Surg 1989; 3: 273-7.
    CrossrefPubMedGoogle Scholar
  • 2 Bainton D, Sweetnam P, Baker I, Elwood P. Peripheral vascular disease: consequence for survival and association with risk factors in the Speedwell prospective heart disease study. Br Heart J 1994; 72: 128-32.
    CrossrefPubMedGoogle Scholar
  • 3 Criqui MH, Langer RD, Fronek A, Feigelson HS, Klauber MR, McCann TJ, Browner D. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med 1992; 326: 381-6.
    CrossrefPubMedGoogle Scholar
  • 4 Brevetti G, Martone VD, Perna S, Cacciatore F, Corrado S, Di Donato AM, Di Iorio A. Intermittent claudication and risk of cardiovascular events. Angiology 1998; 49: 843-8.
    CrossrefPubMedGoogle Scholar
  • 5 Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801-9.
    CrossrefPubMedGoogle Scholar
  • 6 Entman ML, Ballantyne CM. Inflammation in acute coronary syndromes. Circulation 1993; 88: 800-3.
    CrossrefPubMedGoogle Scholar
  • 7 Albelda SM, Wayne Smith C, Ward PA. Adhesion molecules and inflammatory injury. FASEB J 1994; 8: 504-12.
    CrossrefPubMedGoogle Scholar
  • 8 Hwang S-J, Ballantyne CM, Sharrett R, Smith LC, Davis CE, Gotto AM, Boerwinkle E. Circulating adhesion molecules VCAM-1, ICAM-1 and E-selectin in carotid atherosclerosis and incident coronary heart disease cases. The atherosclerosis risk in communities (ARIC) study. Circulation 1997; 96: 4219-25.
    CrossrefPubMedGoogle Scholar
  • 9 Ridker PM, Hennekens CH CH, Roitman-Johnson B, Stampfer MJ, Allen J. Plasma concentrations of soluble intercellular adhesion molecule-1 and risk of future myocardial infarction in apparently healthy men. Lancet 1988; 351: 88-92.
    PubMedGoogle Scholar
  • 10 Drexler H, Zeiher A, Wallsshlager H, Meinertz T, Just H, Bonzel T. Flow-dependent artery dilation in humans. Circulation 1989; 80: 466-74.
    CrossrefPubMedGoogle Scholar
  • 11 Anderson TJ, Ulhata A, Gerhard MD, Meredith IT, Knab S, Delagrange D, Lieherman EH, Ganz P, Creager MA, Yeung AC, Selwyn AP. Close relation of endothelial function in the human coronary and peripheral circulation. J Am Coll Cardiol 1995; 26: 1235-41.
    CrossrefPubMedGoogle Scholar
  • 12 Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE. Endothelium-dependent dilation in the systemic arteries of asyntomatic subjects related to coronary risk factors and their interaction. J Am Coll Cardiol 1994; 24: 1468-74.
    CrossrefPubMedGoogle Scholar
  • 13 Ross R. Atherosclerosis. An inflammatory disease. N Engl J Med 1999; 340: 115-26.
    CrossrefPubMedGoogle Scholar
  • 14 Celermajer DS, Sorensen KE, Gooch VM, Spriegelhalter DJ, Miller OI, Sullivan ID, Lloyd JR, Deanfield JE. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-5.
    CrossrefPubMedGoogle Scholar
  • 15 Cybulsky MI, Gimbrone MA. Endothelial expression of monocyte leukocyte adhesion molecule during atherogenesis. Science 1991; 251: 788-91.
    CrossrefPubMedGoogle Scholar
  • 16 Davies MJ, Gordon JL, Gearing AJH, Pigott R, Woolf H, Katz D, Kyriaopoulos A. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM and E-selectin in human atherosclerosis. J Pathol 1993; 171: 223-9.
    CrossrefPubMedGoogle Scholar
  • 17 O’Brien KD, McDonald TO, Chait A, Allen MD, Alfers CE. Neovascular expression of E-selectin, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. Circulation 1996; 93: 672-82.
    CrossrefPubMedGoogle Scholar
  • 18 Adams DH, Mainolfi E, Elias E, Neuberger J M, Rothlein R. Detection of circulating intercellular adhesion molecule-1 after liver transplantation. Evidence of local release within the liver during graft rejection. Transplantation 1993; 55: 83-7.
    CrossrefPubMedGoogle Scholar
  • 19 Nakay K, Itoh C, Kawazoe K, Miura Y, Sotyanagi H, Hotta K, Itoh T, Kamata J, Hiramori K. Concentration of soluble vascular cell adhesion molecule-1 (VCAM-1) correlated with expression of VCAM-1 mRNA in the human atherosclerotic aorta. Coron Artery Dis 1996; 6: 497-502.
    PubMedGoogle Scholar
  • 20 Newman W, Beall LD, Carson CW, Hunder GG, Graben N, Randhawa ZI, Gopal TV, Wierner-Kronish J, Matthay MA. Soluble E-selectin is found in supernatants of activaed endhotelial cells and is elevated in the serum of patients with septic shock. J Immunol 1993; 150: 644-54.
    PubMedGoogle Scholar
  • 21 Lo SK, Lee S, Ramos RA, Lobb R, Rosa M, Chi-Rosso G W SD. Endothelial-leukocyte adhesion molecule-1 stimulates adhesive activity of leukocyte integrin CR3(Cd11b/CD, alpha m beta 2) on human neutrophils. J Exp Med. 1991; 173 (06) 1493-500.
    CrossrefPubMedGoogle Scholar
  • 22 Fezzi C, Desideri G, Baldoncini R, Bellini C, De Angelis C, Mazzocchi C, Santucci A. Early activation of vascular endothelium in nonobese, nondiabetic essential hypertensive patients with multiple metabolic abnormalities. Diabetes 1998; 47: 660-7.
    CrossrefPubMedGoogle Scholar
  • 23 Davi G, Romano M, Mezzetti A, Procopio A, Iacobelli S, Antidormi T, Bucciarelli T, Alessandrini P, Cuccurullo F, Bittolo Bon G. Increased levels of soluble P-selectin in hypercholesterolemic patients. Circulation 1998; 97: 953-7.
    CrossrefPubMedGoogle Scholar
  • 24 Belch JJ, MacKay IR, Hill A, Jerming P, McCollum P. Oxidative stress is present in atherosclerotic peripheral arterial disease and further increased by diabetes mellitus. Int Ang 1995; 14: 385-8.
    PubMedGoogle Scholar
  • 25 Blann AD, McCollum CN. Circulating endothelial cell/leukocyte adhesion molecules in atherosclerosis. Thromb Haemost 1994; 72: 151-4.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 26 Peter K, Naworoth P, Conradt C, Nordt T, Weiss T, Boehme M, Wunsh A, Allenberg J, Kubler W, Bode C. Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin. Arterioscler Thromb Vasc Biol 1997; 17: 505-12.
    CrossrefPubMedGoogle Scholar