Rapid Intracellular Degradation of a Truncated Mutant Protein S (Q522X)

Thromb Haemost 2002; 87(01): 171-172
DOI: 10.1055/s-0037-1612963

Letters to the Editor

Schattauer GmbH

Tomio Yamazaki

¹Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Malmö, Sweden

²First Department of Internal Medicine, Nagoya University, School of Medicine, Nagoya, Japan

,

Hidehiko Saito

²First Department of Internal Medicine, Nagoya University, School of Medicine, Nagoya, Japan

³Nagoya National Hospital, Nagoya, Japan

,

Björn Dahlbäck

¹Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Malmö, Sweden

References
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2 Yamazaki T, Hamaguchi M, Katsumi A, Kagami K, Kojima T, Takamatsu J, Saito H. A quantitative protein S deficiency associated with a novel nonsense mutation and markedly reduced levels of mutated mRNA. Thromb Haemost 1995; 74: 590-5.
3 Yamazaki T, Katsumi A, Kagami K, Okamoto Y, Sugiura I, Hamaguchi M, Kojima T, Takamatsu J, Saito H. Molecular basis of a hereditary type I protein S deficiency caused by a substitution of Cys for Arg474. Blood 1996; 87: 4643-50.
4 Espinosa-Parrilla Y, Yamazaki T, Sala N, Dahlbäck B, Garcia de Frutos P. Protein S secretion differences of missense mutants account for phenotypic heterogeneity. Blood 2000; 95: 173-9.