Download PDF
Thromb Haemost 2002; 87(01): 173-174
DOI: 10.1055/s-0037-1612965
Letters to the Editor
Schattauer GmbH

Is Homozygosity for the HR2 Haplotype a Risk Factor for Venous Thromboembolism?

Omer Aras
1   Department of Medicine, University of Minnesota Medical School. MMC 480 Mayo Building, Minneapolis, MN, USA
,
Naomi Q. Hanson
1   Department of Medicine, University of Minnesota Medical School. MMC 480 Mayo Building, Minneapolis, MN, USA
,
Michael Y. Tsai
1   Department of Medicine, University of Minnesota Medical School. MMC 480 Mayo Building, Minneapolis, MN, USA
,
Nigel S. Key
1   Department of Medicine, University of Minnesota Medical School. MMC 480 Mayo Building, Minneapolis, MN, USA
› Author Affiliations
Further Information

Publication History

Received 16 August 2001

Accepted 17 August 2001

Publication Date:
14 December 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Lunghi B, Iacoviello L, Gemmati D, Dilaso MG, Castoldi E, Pinotti M, Castaman G, Redaelli R, Mariani G, Marchetti G, Bernardi F. Detection of new polymorphic markers in the factor V gene: association with factor V levels in plasma. Thromb Haemost 1996; 75: 45-8.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Bernardi F, Faioni EM, Castoldi E, Lunghi B, Castaman G, Sacchi E, Mannucci PM. A factor V genetic component differing from factor V R506Q contributes to the activated protein C resistance phenotype. Blood 1997; 90: 1552-7.
    PubMedGoogle Scholar
  • 3 Alhenc-Gelas M, Nicaud M, Gandrille S, van Dreden P, Amiral J, Aubry ML, Fiessinger JN, Emmerich J, Aiaich M. The factor V gene A4070G mutation and the risk of venous thrombosis. Thromb Haemost 1999; 81: 193-7.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Luddington R, Jackson R, Pannerselvam S, Brown K, Baglin T. The factor R2 allele: risk of venous thromboembolism, factor V levels and resistance to activated protein C. Thromb Haemost 2000; 83: 204-8.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 De Visser MCH, Guasch JF, Kamphuisen PW, Vos HL, Rosendaal FR, Bertina RM. The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis. Thromb Haemost 2000; 83: 577-82.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Faioni EM, Franchi F, Bucciarelli P, Margaglione M, De Stefano V, Castaman G, Finazzi G, Mannucci PM. Coinheritance of the HR2 haplotype in the factor V gene confers an increased risk of venous thromboembolism to carriers of factor V R506Q (factor V Leiden). Blood 1999; 94: 3062-6.
    PubMedGoogle Scholar
  • 7 Folsom AR, Cushman M, Tsai MY, Aleksic N, Heckbert SR, Boland LL, Tsai AW, Yanez ND, Rosamond WD. Prospective study of venous thromboembolism in relation to factor V Leiden and related factors: the Longitudinal Investigation of Thromboembolism Etiology (LITE). Thromb Haemost 2001; 86 Suppl 325a.
    PubMedGoogle Scholar
  • 8 Castoldi E, Rosing J, Girelli D, Hoekema L, Lunghi B, Mingozzi F, Ferraresi F, Ferraresi P, Friso S, Corrocher R, Tans G, Bernardi F. Mutations in the R2 FV gene affect the ratio between the two FV isoforms in plasma. Thromb Haemost 2000; 83: 362-5.
    Article in Thieme ConnectPubMedGoogle Scholar