Association of Factor V Leiden Mutation with Delayed Graft Function, Acute Rejection Episodes and Long-term Graft Dysfunction in Kidney Transplant Recipients

Berthold Hocher; Torsten Slowinski; Ingeborg Hauser; Birgit Vetter; Lutz Fritsche; Daniela Bachert; Andreas Kulozik; Hans-H. Neumayer

doi:10.1055/s-0037-1612972

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2002; 87(02): 194-198
DOI: 10.1055/s-0037-1612972

Review Article

Schattauer GmbH

Association of Factor V Leiden Mutation with Delayed Graft Function, Acute Rejection Episodes and Long-term Graft Dysfunction in Kidney Transplant Recipients

Berthold Hocher

¹Departments of Nephrology

²Institute of Molecular Biology and Biochemistry, University Hospital Benjamin Franklin, Free University of Berlin, Berlin

,

Torsten Slowinski

¹Departments of Nephrology

²Institute of Molecular Biology and Biochemistry, University Hospital Benjamin Franklin, Free University of Berlin, Berlin

,

Ingeborg Hauser

³Department of Nephrology, University Hospital Erlangen-Nürnberg, Nürnberg, Germany

,

Birgit Vetter

⁴General Paediatrics, University Hospital Charité, Humboldt University of Berlin, Berlin

,

Lutz Fritsche

¹Departments of Nephrology

,

Daniela Bachert

¹Departments of Nephrology

²Institute of Molecular Biology and Biochemistry, University Hospital Benjamin Franklin, Free University of Berlin, Berlin

,

Andreas Kulozik

⁴General Paediatrics, University Hospital Charité, Humboldt University of Berlin, Berlin

,

Hans-H. Neumayer

¹Departments of Nephrology

› Author Affiliations

Abstract

Summary

We analysed whether the factor V Leiden mutation – the most common hereditary predisposing factor for venous thrombosis – is associated with early and long-term graft dysfunction after kidney transplantation in 394 Caucasian kidney transplant recipients. The presence of factor V Leiden mutation was identified by allele specific PCR. The prevalence of the factor V Leiden mutation was compared to 32216 unselected neonates. The prevalence of the factor V Leiden mutation (GA genotype) was similar in 394 kidney transplant recipients and 32216 neonates. The frequency of known factors predicting long-term graft function were similar in patients with the GA genotype and with the normal factor V gene (GG genotype). The GA genotype was associated with the occurrence of no primary graft function (risk: 2.87; 95% confidence interval: 1.01-8.26; p < 0.05), the number of dialysis after transplantation in patients with no primary graft function until graft function (7.5 ± 2.06 dialysis in GA patients; 4.2 ± 0.36 dialyses in GG patients; p < 0.05), and the risk for at least one acute rejection episode (risk: 3.83; 95% confidence interval: 1.38-10.59; p < 0.02). The slope of 1/creatinine per year was significantly lower in patients with the GA genotype (GA patients: – 0.0204 ± 0.008 dl/mg per year; GG patients: 0.0104 ± 0.004 dl/mg per year; p < 0.02). The annual enhancement of the daily protein excretion rate was elevated in patients with the GA genotype (GA patients: 38.5 ± 16.6 mg/24 h per year; GG patients: 4.9 ± 4.4 mg/24 h per year; p < 0.02). Our study showed that the factor V Leiden mutation is associated with the occurrence of delayed graft function, acute rejection episodes and chronic graft dysfunction after kidney transplantation.

Keywords

Factor V Leiden mutation - kidney transplantation

Full Text

References

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