Factor VII Activation, Apolipoprotein A-I and Reverse Cholesterol Transport: Possible Relevance for Postprandial Lipaemia

G. J. Miller; C. J. Cooke; M. N. Nanjee; D. J. Howarth; J. A. Cooper; I. P. Stepanova; J. H. Morrissey; N. E. Miller

doi:10.1055/s-0037-1613028

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2002; 87(03): 477-482
DOI: 10.1055/s-0037-1613028

Review Article

Schattauer GmbH

Factor VII Activation, Apolipoprotein A-I and Reverse Cholesterol Transport: Possible Relevance for Postprandial Lipaemia

G. J. Miller

¹MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, London, UK

,

C. J. Cooke

²Department of Cardiovascular Biochemistry, St Bartholomew’s and Royal London School of Medicine and Dentistry, London, UK

,

M. N. Nanjee

²Department of Cardiovascular Biochemistry, St Bartholomew’s and Royal London School of Medicine and Dentistry, London, UK

,

D. J. Howarth

¹MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, London, UK

,

J. A. Cooper

¹MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, London, UK

,

I. P. Stepanova

²Department of Cardiovascular Biochemistry, St Bartholomew’s and Royal London School of Medicine and Dentistry, London, UK

,

J. H. Morrissey

³Department of Biochemistry, University of Illinois College of Medicine, Urbana, IL, USA

,

N. E. Miller

²Department of Cardiovascular Biochemistry, St Bartholomew’s and Royal London School of Medicine and Dentistry, London, UK

› Author Affiliations

Abstract

Summary

Postprandial lipaemia is associated with activation of factor VII (FVII) and efflux of cholesterol from tissues to nascent plasma high density lipoproteins (HDL) containing apolipoprotein A-I (apo A-I). To determine whether FVII activation and cholesterol efflux occur together in other situations, the responses to intravenous infusion of HDL-like apo A-I/phosphatidylcholine discs were measured in 10 healthy men. Disc infusion (40 mg apo A-I/kg body weight) over 4 h was followed by increases in HDL cholesteryl ester and plasma apo A-I (p <0.0001). Significant activation of FVII was apparent during infusion in fasting subjects (p = 0.03), activated FVII averaging 123% of baseline value by 12 h (p <0.0001). Plasma thrombin-antithrombin (TAT) complex increased to 156% of baseline level by 12 h (p >0.05) but individual responses differed considerably. Peak TAT post-infusion was associated inversely with peak HDL triglyceride concentration (p = 0.004). The coagulation responses to disc-infusion may be due to transfer of phosphatidylserine to cell surfaces during cholesterol efflux.

Keywords

Factor VII - apolipoprotein A-I - high density lipoprotein - phospholipids - reverse cholesterol transport

Full Text

References

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