Patients with Essential Thrombocythaemia have an Increased Prevalence of Antiphospholipid Antibodies which may be associated with Thrombosis

C.N. Harrison; S. Donohoe; P. Carr; M. Dave; I. Mackie; S.J. Machin

doi:10.1055/s-0037-1613087

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2002; 87(05): 802-807
DOI: 10.1055/s-0037-1613087

Review Article

Schattauer GmbH

Patients with Essential Thrombocythaemia have an Increased Prevalence of Antiphospholipid Antibodies which may be associated with Thrombosis

C.N. Harrison

¹Department of Haematology, University College London Hospital, UK

,

S. Donohoe

¹Department of Haematology, University College London Hospital, UK

,

P. Carr

¹Department of Haematology, University College London Hospital, UK

,

M. Dave

¹Department of Haematology, University College London Hospital, UK

,

I. Mackie

¹Department of Haematology, University College London Hospital, UK

,

S.J. Machin

¹Department of Haematology, University College London Hospital, UK

› Institutsangaben

Abstract

Summary

A significant proportion of patients with Essential Thrombocythaemia (ET) have thrombotic complications which have an important impact upon the quality, and duration of their life. We performed a retrospective cross sectional study of the prevalence of antiphospholipid antibodies (APA) in 68 ET patients. Compared to 200 “elderly” controls (> 50 years) there was a significant increase in anticardiolipin IgM (p < 0.0001) and anti β₂ glycoprotein I (anti-β₂GPI) IgM (p < 0.0001) antibodies in ET. Thrombosis occurred in 10/20 with APA and 12/48 without, p = 0.04, relative risk 2.0 (95% confidence intervals 1.03–3.86); these patients did not differ in terms of other clinical features. The prevalence of thrombosis in patients with dual APA (6/7) was significant when compared to those with single APA (p = 0.02) and the remaining patients (p < 0.0002). Also anti-β₂GP1 IgM antibodies either alone, or in combination with another APA, were associated with thrombosis (p = 0.02). These results suggest that the prevalence of APA in ET and their influence upon thrombotic risk merit investigation in a larger study.

Keywords

ET - antiphospholipid antibodies - thrombosis

Volltext

Referenzen

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