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Thromb Haemost 2002; 87(06): 972-977
DOI: 10.1055/s-0037-1613120
Review Article
Schattauer GmbH

Factor V Leiden and Prothrombin Gene G20210A Mutation in Children with Venous Thromboembolism

Mariana Bonduel
1   Servicio de Hematología-Oncología, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
,
Mirta Hepner
1   Servicio de Hematología-Oncología, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
,
Gabriela Sciuccati
1   Servicio de Hematología-Oncología, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
,
Graciela Pieroni
1   Servicio de Hematología-Oncología, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
,
Aurora Feliú-Torres
1   Servicio de Hematología-Oncología, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
,
Claudia Mardaraz
1   Servicio de Hematología-Oncología, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
,
Juan Pablo Frontroth
1   Servicio de Hematología-Oncología, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina
› Institutsangaben
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Publikationsverlauf

Received 17. September 2001

Accepted after resubmission 20. Februar 2002

Publikationsdatum:
08. Dezember 2017 (online)

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Summary

To determine whether factor V Leiden (FVL) and/or prothrombin gene G20210A mutation (PT20210A) are risk factors for venous thromboembolism (VTE) in Argentinean children. One hundred and thirty consecutive children with VTE were prospectively assisted at a single centre. Blood samples were available from 110 of them for detailed haematological analysis. The prevalence of both mutations was compared with a control group. The odds ratio for VTE was significantly increased in patients with FVL (OR 3.64; 95% CI: 1.14-11.6, p <0.029) whereas odds ratio for VTE was not significantly increased in patients with PT20210A (OR 1.06; 95% CI: 0.24-4.73, p = 0.938). Combined disorders were found in 5 of the 10 children with the aforementioned mutations. In 21 children (19%) without these mutations other inherited and acquired disorders were detected. Our data show that FVL is a risk factor for VTE whereas PT20210A does not seem to be a risk factor in our paediatric population.

Keywords

Venous thromboembolism - Factor V Leiden - prothrombin gene G20210A mutation - children - prothrombotic abnormalities
 

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