Effect of Coenzyme Q10 and Ginkgo biloba on Warfarin Dosage in Stable, Long-term Warfarin Treated Outpatients. A Randomised, Double Blind, Placebo-crossover Trial

J. Engelsen; J.D. Nielsen; K. Winther

doi:10.1055/s-0037-1613135

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2002; 87(06): 1075-1076
DOI: 10.1055/s-0037-1613135

Letters to the Editor

Schattauer GmbH

Effect of Coenzyme Q₁₀ and Ginkgo biloba on Warfarin Dosage in Stable, Long-term Warfarin Treated Outpatients. A Randomised, Double Blind, Placebo-crossover Trial

J. Engelsen

¹Thrombosis Centre and Coagulation Laboratory, Department of Clinical Biochemistry, Copenhagen County Hospital in Gentofte, University of Copenhagen, Hellerup, Denmark

,

J.D. Nielsen

¹Thrombosis Centre and Coagulation Laboratory, Department of Clinical Biochemistry, Copenhagen County Hospital in Gentofte, University of Copenhagen, Hellerup, Denmark

,

K. Winther

¹Thrombosis Centre and Coagulation Laboratory, Department of Clinical Biochemistry, Copenhagen County Hospital in Gentofte, University of Copenhagen, Hellerup, Denmark

› Author Affiliations

Abstract

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References

References
1 Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994; 344: 1372-3.
2 Landbo C, Almdal TP. Drug interaction between warfarin and coenzyme Q₁₀ . Ugeskr Læger 1998; 160: 2326-7.
3 Jensen K. Risk by taking food supplements, natural medicine and herbal tea. Ugeskr Læger 1999; 161: 266-70.
4 Nielsen JD, Husted SE, Lassen JF, Nielsen HK, Winther KFH, Antonsen S. et al. Anticoagulant treatment. Ugeskr Læger 2000; 162: 1247-52.
5 Greenberg S, Frishman WH. Co-enzyme Q₁₀: a new drug for cardiovascular disease. J Clin Pharmacol 1990; 30: 596-608.
6 Peppings J. Alternative Therapies: Coenzyme Q₁₀ . Am J Health Syst Pharm 1999; 56: 519-21.
7 Kleijnen J, Knipschild P. Ginkgo biloba. Lancet 1992; 340: 1136-9.
8 Chung KF, McCusker M, Page CP, Dent G, Guinot PH, Barnes PJ. Effect of a Ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. Lancet 1987; 01: 248-51.
9 Rowin J. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 1996; 46: 1775-76.
10 Vale S. Subarachnoid haemorrhage associated with Ginkgo biloba. Lancet 1998; 352: 36.