Differential Effects of Moderate or Heavy Alcohol Consumption on Circulating Adhesion Molecule Levels

E. Sacanella; E. Badía; J. M. Nicolás; J. Fernández-Solá; E. Antúnez; A. Urbano-Márquez; R. Estruch

doi:10.1055/s-0037-1613153

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2002; 88(01): 52-55
DOI: 10.1055/s-0037-1613153

Review Article

Schattauer GmbH

Differential Effects of Moderate or Heavy Alcohol Consumption on Circulating Adhesion Molecule Levels

E. Sacanella

¹Department of Internal Medicine, Hospital Clínic, Institut d’Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), University of Barcelona, Spain

,

E. Badía

¹Department of Internal Medicine, Hospital Clínic, Institut d’Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), University of Barcelona, Spain

,

J. M. Nicolás

¹Department of Internal Medicine, Hospital Clínic, Institut d’Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), University of Barcelona, Spain

,

J. Fernández-Solá

¹Department of Internal Medicine, Hospital Clínic, Institut d’Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), University of Barcelona, Spain

,

E. Antúnez

¹Department of Internal Medicine, Hospital Clínic, Institut d’Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), University of Barcelona, Spain

,

A. Urbano-Márquez

¹Department of Internal Medicine, Hospital Clínic, Institut d’Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), University of Barcelona, Spain

,

R. Estruch

¹Department of Internal Medicine, Hospital Clínic, Institut d’Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), University of Barcelona, Spain

› Institutsangaben

Abstract

Summary

Epidemiological studies suggest that moderate but not heavy alcohol consumption provides protection against coronary heart disease. We assessed the relationship between alcohol consumption and serum levels of adhesion molecules involved in the pathogenesis of early atherosclerosis. One-hundred apparently healthy men with similar cardiovascular risk factors were divided into four groups according to ethanol intake. Moderate drinkers (20-40 g/day) showed lower serum intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) levels than abstainers (p <0.05; both), as well as lower serum ICAM-1, VCAM-1 and E-selectin levels than heavy drinkers (p = 0.01; all). The latter also showed higher serum ICAM-1 and E-selectin levels than abstainers (p <0.001; both). We conclude that moderate drinkers show a significant reduction of soluble endothelial adhesion molecule levels compared to abstainers and heavy drinkers, that may contribute to the protective effect of moderate alcohol consumption against atherosclerosis.

Keywords

VCAM-1 - E-selectin - ICAM-1 - alcohol consumption - atherosclerosis

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Referenzen

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