Thromb Haemost 2002; 88(01): 111-114
DOI: 10.1055/s-0037-1613162
Review Article
Schattauer GmbH

Studies on Reference Intervals for Platelet Counts in Three Cities in China and one in Japan

Changgeng Ruan
1   Suzhou University Medical College 1st Hospital, China
,
Yun Wu
1   Suzhou University Medical College 1st Hospital, China
,
Tokuhiro Okada
2   Sysmex Corporation, Japan
,
Shigemi Motoi
2   Sysmex Corporation, Japan
,
Tamiaki Kondo
2   Sysmex Corporation, Japan
,
Meiyi Jiang
2   Sysmex Corporation, Japan
,
Xiaomin Xin
3   Harbin Medical University 1st Hopital, China
,
Liming Peng
4   1st University Hospital West China University of Medical Science, China
,
Kiyoshi Ichihara
5   Kawasaki Medical School, Japan
,
Yasuo Ikeda
6   Keio University School of Medicine, Japan
› Author Affiliations
Further Information

Publication History

Received 09 October 2001

Accepted after resubmission 12 March 2002

Publication Date:
09 December 2017 (online)

Summary

Hematological parameters including platelet counts, etc. were determined in 1,140 healthy subjects living in four cities: Suzhou (Jiangsu Province), Chengdu (Sichuan Province) and Harbin (Heilongjang Province) in China, and Kobe in Japan. Then, the reference intervals for platelet counts were calculated and compared. The reference interval for platelet count of subjects aged between 18 and 60 years was 60-259 × 109/L in Suzhou and 52–202 × 109/L in Chengdu, and subjects with platelet counts of 100 × 109/L or less accounted for about 30% of the subjects examined in these cities. The reference intervals in Harbin and Kobe were within the range of 150–350 × 109/L, and no subject having a platelets count of 100 × 109/L or less was detected. Mean platelet volume (MPV) determined concurrently was negatively correlated with platelet count, and the reference intervals for MPV in Chengdu and Suzhou were higher than those in Harbin and Kobe.

 
  • References

  • 1 NCCLS Document. How to define and determine reference intervals in the clinical laboratory; approved guidelines. NCCLS Document C28-A 1995 Vol. 15. No. 4.
  • 2 Ichihara K, Kawai T. Determination of reference intervals for 13 plasma proteins based on IFCC international reference preparation (CRM 470) and NCCLS proposed guideline C28-P, 1992; trial to select reference individuals by results of screening tests and application of maximal likelihood method. J Clin Lab Anal 1996; 10: 110-7.
  • 3 Lewis SM, Rowan RM, Kubota F. Evaluation of a prototype for a reference platelet counter. J Clin Pathol 1990; 43: 932-6.
  • 4 Kienast J, Schmitz G. Flow cytometric analysis of thiazole orange uptake by platelets: a diagnostic aid in the evaluation of thrombocytopenic disorders. Blood 1990; 75: 116-21.
  • 5 Bessman JD, Williams LJ, Gilmer PR. Mean platelet volume: inverse relation between platelet count and size in normal subjects and artifact of other particles. Am J Clin Pathol 1981; 76: 289-93.
  • 6 Wintrobe’s Clinical Hematology. Sixth edition. Philadelphia: Lea & Febiger, London; 1967
  • 7 Wintrobe’s Clinical Hematology. Ninth edition. Vol. 2 Philadelphia, London: Lea & Febiger; 1993
  • 8 Brummitt DR, Berker HF. The determination of a reference range for new platelet parameters produced by the Bayer ADVIA™ 120 full blood count analyser. Clin Lab Heamatol 2000; 22: 103-7.
  • 9 Fleger-Mestric Z, Nazor A, Jagarinec N. Heamatological profile in healthy urban population (8 to 70 years of age). Coll Antropol 2000; 24: 185-96.
  • 10 Harkar LA, Slichter SJ. The bleeding time as a screening test for evaluation of platelet function. N Engl J Med 1972; 287: 155-9.
  • 11 William’s Hematology. Sixth edition. New York: McGraw-Hill; 2001
  • 12 Rustemeijer C, Bilo HJG, Beukhof JR, Schouten JC, Mulder C, Donker AJM. The effect of fish oil concentrate on serum lipids and lipoproteins in patients on maintenance hemodialysis. Current Therapeutic Research 1988; 43: 559-67.