The G7763C Endothelial Protein C Receptor (EPCR) Gene Mutation: Prevalence and Association with DVT in the Irish Population

Leeona Galligan; Conor Powell; Wendy Livingstone; Lesley Mynett-Johnston; Owen P. Smith

doi:10.1055/s-0037-1613174

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2002; 88(01): 163-165
DOI: 10.1055/s-0037-1613174

Letters to the Editor

Schattauer GmbH

The G7763C Endothelial Protein C Receptor (EPCR) Gene Mutation: Prevalence and Association with DVT in the Irish Population

Leeona Galligan

¹National Centre for Hereditary Coagulation Disorders, St James’s Hospital

²Smurfit Institute of Genetics, Trinity College Dublin, Ireland

,

Conor Powell

²Smurfit Institute of Genetics, Trinity College Dublin, Ireland

,

Wendy Livingstone

¹National Centre for Hereditary Coagulation Disorders, St James’s Hospital

²Smurfit Institute of Genetics, Trinity College Dublin, Ireland

,

Lesley Mynett-Johnston

²Smurfit Institute of Genetics, Trinity College Dublin, Ireland

,

Owen P. Smith

¹National Centre for Hereditary Coagulation Disorders, St James’s Hospital

²Smurfit Institute of Genetics, Trinity College Dublin, Ireland

› Author Affiliations

Abstract

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References

References
1 Esmon CT. The protein C anticoagulant pathway. Arterioscler Thromb 1992; 12: 135-45.
2 Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA 1996; 93: 10212-6.
3 Laszik Z, Mitro A, Taylor Jr FB, Ferrell G, Esmon CT. Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway. Circulation 1997; 96: 3633-40.
4 Fukudome K, Ye X, Tsuneyoshi N, Tokunaga O, Sugawara K, Mizokami H, Kimoto M. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. J Exp Med 1998; 187: 1029-35.
5 Hayashi T, Nakamura H, Okada A, Takebayashi S, Wakita T, Yuasa H, Suzuki K. Organization and chromosomal localization of the human endothelial protein C receptor gene. Gene 1999; 238: 367-73.
6 Villoutreix BO, Blom AM, Dahlback B. Structural prediction and analysis of endothelial cell protein C/activated protein C receptor. Protein Eng 1999; 12: 833-40.
7 Fukudome K, Esmon CT. Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 1994; 269: 26486-91.
8 Espana F, Medina P, Estelles MA, Vaya A, Villa P, Royo M, Aznar J, Bertina RM. A new polymorphism in the 3’ UTR of the endothelial protein C receptor is associated with increased levels of circulating activated protein C and decreased risk of venous thrombosis. X VHIth Congress of the International Society of Thrombosis and Haemostasis; Paris, France: Thromb Ftaemost. 2001. Abstracts (Suppl): (Abstr no 885)