Measurable Differences between Sequential and Parallel Diagnostic Decision Processes for Determining Stroke Subtype: A Representation of Interacting Pathologies

Cathy M. Helgason; Fred A. Watkins; Thomas H. Jobe

doi:10.1055/s-0037-1613189

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2002; 88(02): 210-212
DOI: 10.1055/s-0037-1613189

In Focus

Schattauer GmbH

Measurable Differences between Sequential and Parallel Diagnostic Decision Processes for Determining Stroke Subtype: A Representation of Interacting Pathologies

Cathy M. Helgason

¹Department of Neurology, University of Illinois College of Medicine, Chicago, Illinois

,

Fred A. Watkins

²HyperLogic Corporation, Escondido, California

,

Thomas H. Jobe

³Department of Psychiatry, University of Illinois College of Medicine, Chicago, Illinois, USA

› Author Affiliations

Abstract

Summary

Stroke diagnosis depends on causal subtype. The accepted classification procedure is a succession of diagnostic tests administered in an order based on prior reported frequencies of the subtypes. The first positive test result completely determines diagnosis. An alternative approach tests multiple concomitant diagnostic hypotheses in parallel. This method permits multiple simultaneous pathologies in the patient. These two diagnostic procedures can be compared by novel numeric criteria presented here.

Thrombosis, a type of ischemic stroke, results from interaction between endothelium, blood flow and blood components. We tested for ischemic stroke on thirty patients using both methods. For each patient the procedure produced an assessment of severity as an ordered set of three numbers in the interval [0, 1]. We measured the difference in diagnosis between the sequential and parallel diagnostic algorithms. The computations reveal systematic differences: The sequential procedure tends to under-diagnose and excludes any measure of interaction between pathologic elements.

Keywords

Stroke subtype - diagnosis - pathogenesis - cause - interaction - ischemic stroke

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References

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