Relationship between C-5T Kozak, C807T Genotypes and Expression of Glycoproteins Ibα and Ia-IIa at Platelet Surface: From Genotype to Phenotype

Thromb Haemost 2002; 88(02): 368
DOI: 10.1055/s-0037-1613217

Letters to the Editor

Schattauer GmbH

L Macchi

¹Laboratoire d’hématologie et des maladies du sang

,

N Sorel

¹Laboratoire d’hématologie et des maladies du sang

,

S Brabant

¹Laboratoire d’hématologie et des maladies du sang

,

L Christiaens

²Département de cardiologie

,

G Mauco

³EA 1223, GEMCI, Faculté de Médecine et Pharmacie, Hôpital La Milétrie, CHU Poitiers, Poitiers, France

References
1 Santoso S. Platelet polymorphisms in thrombotic disorders. Transfus Clin Biol 2001; 08: 261-6.
2 Kunicki TJ, Kritzik M, Annis DS, Nugent DJ. Hereditary variation in platelet integrin α2β1 density is associated with two silent polymorphisms in the α2 gene coding sequence. Blood 1997; 89: 1939-43.
3 Afshar-Karghan V, Li CQ, Khoshnevis-Asl M, Lopez JA. Kozak sequence polymorphism of the glycoprotein (GP) Ibα gene is a major determinant of the plasma membrane levels of the platelet GP Ib-IX-V complex. Blood 1999; 94: 186-91.
4 Corral J, Lozano ML, Gonzalez-Conejero R, Martinez C, Iniesta JA, Rivera J, Vicente V. A common polymorphism flanking the ATG initiator codon of GpIba does not affect expression and is not a major risk factor for arterial thrombosis. Thromb Haemost 2000; 83: 23-8.
5 Croft SA, Hampton KK, Sorrel JA, Steeds RP, Channer KS, Samani NJ, Daly ME. The GPIa C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction. Br J Haematol 1999; 106: 771-6.