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Thromb Haemost 2002; 88(02): 374-375
DOI: 10.1055/s-0037-1613223
Letters to the Editor
Schattauer GmbH

What Can We Learn from the Immune Response to Human Factor VIII in a Mouse Model of Hemophilia A?

B.M. Reipert
1   Baxter BioScience, Vienna, Austria
,
H.P. Schwarz
1   Baxter BioScience, Vienna, Austria
› Institutsangaben
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Publikationsverlauf

Received 21. März 2002

Accepted 21. März 2002

Publikationsdatum:
07. Dezember 2017 (online)

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  • References

  • 1 Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD, Kazazian Jr HH. Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nat Genet 1995; 10: 119-21.
    CrossrefPubMedSuche in Google Scholar
  • 2 Bi L, Sarkar R, Naas T, Lawler AM, Pain J, Shumaker SL, Bedian V, Kazazian HH. Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies. Blood 1996; 88: 3446-50.
    PubMedSuche in Google Scholar
  • 3 Muchitsch EM, Turecek PL, Zimmermann K, Pichler L, Auer W, Richter G, Gritsch H, Schwarz HP. Phenotypic expression of murine hemophilia (letter). Thromb Haemost 1999; 82: 1371-3.
    Thieme ConnectPubMedSuche in Google Scholar
  • 4 Connelly S, Andrews JL, Gallo AM, Kayda DB, Qian J, Hoyer L, Kadan MJ, Gorziglia MI, Trapnell BC, McClelland A, Kaleko M. Sustained phenotypic correction of murine hemophilia A by in vivo gene therapy. Blood 1998; 91: 3273-81.
    PubMedSuche in Google Scholar
  • 5 Qian J, Borovok M, Bi L, Kazazian Jr HH, Hoyer LW. Inhibitor development and T cell response to human factor VIII in murine haemophilia A. Thromb Haemost 1999; 81: 240-4.
    Thieme ConnectPubMedSuche in Google Scholar
  • 6 Reipert BM, Ahmad RU, Turecek PL, Schwarz HP. Characterization of antibodies induced by human factor VIII in a murine knockout model of hemophilia A. Thromb Haemost 2000; 84: 826-32.
    Thieme ConnectPubMedSuche in Google Scholar
  • 7 Balague C, Zhou J, Dai Y, Alemany R, Josephs SF, Andreason G, Hariharan M, Sethi E, Prokopenko E, Jan HY, Lou YC, Hubert-Leslie D, Ruiz L, Zhang WW. Sustained high-level expression of full-length human factor VIII and restoration of clotting activity in hemophilic mice using a minimal adenovirus vector. Blood 2000; 95: 820-8.
    PubMedSuche in Google Scholar
  • 8 Elder B, Lakich D, Gitschier J. Sequence of the murine factor VIII cDNA. Genomics 1993; 16: 374-9.
    CrossrefPubMedSuche in Google Scholar
  • 9 Coughlin SR. Thrombin signaling and protease-activated receptors. Nature 2000; 407: 258-64.
    CrossrefPubMedSuche in Google Scholar
  • 10 Vergnolle N, Wallace JL, Bunnett NW, Hollenberg MD. Protease-activated receptors in inflammation, neuronal signalling and pain. Trends Pharmacol Sci 2001; 22: 146-52.
    CrossrefPubMedSuche in Google Scholar
  • 11 Cunningham MA, Romas P, Hutchinson P, Holdsworth SR, Tipping PG. Tissue factor and factor VIIa receptor/ligand interactions induce proinflammatory effects in macrophages. Blood 1999; 94: 3413-20.
    PubMedSuche in Google Scholar
  • 12 Schwaab R, Brackmann HH, Meyer C, Seehafer J, Kirchgesser M, Haack A, Olek K, Tuddenham EG, Oldenburg J. Haemophilia A: Mutation type determines risk of inhibitor formation. Thromb Haemost 1995; 74: 1402-6.
    Thieme ConnectPubMedSuche in Google Scholar
  • 13 Reipert BM, Sasgary M, Ahmad RU, Auer W, Turecek PL, Schwarz HP. Blockade of CD40/CD40 ligand interactions prevents induction of factor VIII inhibitors in hemophilic mice but does not induce lasting immune tolerance. Thromb Haemost 2001; 86: 1345-52.
    Thieme ConnectPubMedSuche in Google Scholar
  • 14 Qian J, Burkly LC, Smith EP, Ferrant JL, Hoyer LW, Scott DW, Haudenschild CC. Role of CD154 in the secondary immune response: the reduction of pre-existing splenic germinal centers and anti-factor VIII inhibitor titers. Eur J Immunol 2000; 30: 2548-54.
    CrossrefPubMedSuche in Google Scholar
  • 15 Sarkar R, Gao GP, Chirmule N, Tazelaar J, Kazazian HH. Partial correction of the murine hemophilia A with neo-antigenic murine factor VIII. Hum Gene Ther 2000; 11: 881-94.
    CrossrefPubMedSuche in Google Scholar