Plasma Prothrombin Levels are not Associated with Mutations in the Promoter Region of the Prothrombin Gene

Sepideh Akhavan; Silvia Lavoretano; Veena Chantarangkul; Pier Mannuccio Mannucci

doi:10.1055/s-0037-1613320

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2002; 88(05): 877-878
DOI: 10.1055/s-0037-1613320

Letters to the Editor

Schattauer GmbH

Plasma Prothrombin Levels are not Associated with Mutations in the Promoter Region of the Prothrombin Gene

Sepideh Akhavan

¹Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milan, Italy

,

Silvia Lavoretano

¹Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milan, Italy

,

Veena Chantarangkul

¹Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milan, Italy

,

Pier Mannuccio Mannucci

¹Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milan, Italy

› Author Affiliations

Abstract

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References

References
1 Poort SR, Rosenthal FR, Reisma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
2 Hillarp A, Zoller B, Svensson PJ, Dahlbäck B. The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis. Thromb Haemost 1998; 78: 990-2.
3 Babcroft JD, Schaefer LA, Degen SJ. Characterisation of the Alu-rich 5’-flanking region of the human protoombin-encoding gene: identification of a positive cis-acting element that regulates liver-specific expression. Gene 1990; 95: 253-60.
4 Cattaneo M, Chantarangkul V, Taioli E, Santos JH, Tagliabue L. The G20210A mutation of the prothrombin gene in patients with previous first episodes of deep-vein thrombosis: prevalence and association with factor G1691 A, mefliylenetetrahydrofolate reductase C677T and plasma prothrombin levels. Thromb Res 1999; 93: 1-8.
5 Zivelin A, Rosenberg N, Faier S, Kornbrot N, Peterz H, Mannhalter C, Horellou MH, Seligsohn U. A single genetic origin for the common pro toombotic G20210A polymorphism in the protoombin gene. Blood 1998; 92: 1119-24.
6 Ceelie H, Bertina RM, Van Hylckama AVlieg, Rosendaal FR, Vos HL. Polymorphisms in the prothrombin gene and their association with plasma prothrombin levels. Thromb Haemost 2001; 85: 1066-70.
7 Mitchell PJ, Tjian R. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 1989; 245: 371-8.
8 Maniatis T, Goodbourn S, Fischer JA. Regulation of inducible and tissue-specific gene expression. Science 1987; 236: 1237-45.