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Thromb Haemost 2003; 89(05): 771-772
DOI: 10.1055/s-0037-1613460
Editorial
Schattauer GmbH

The blissful state of endothelium

Mauro Maccarrone
1   Department of Biomedical Sciences, University of Teramo, Teramo, Italy
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Publication Date:
09 December 2017 (online)

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  • References

  • 1 McAllister SD, Glass M.. CB1 and CB2 receptor-mediated signalling: a focus on endocannabinoids. Prostaglandins Leukot Essent Fatty Acids 2002; 66: 161-71.
    CrossrefPubMedGoogle Scholar
  • 2 Mechoulam R, Panikashvili D, Shohami E.. Cannabinoids and brain injury: therapeutic implications. Trends Mol Med 2002; 8: 58-61.
    CrossrefPubMedGoogle Scholar
  • 3 Pertwee RG.. Cannabinoid receptors and pain. Prog Neurobiol 2001; 63: 569-611.
    CrossrefPubMedGoogle Scholar
  • 4 Maccarrone M, Finazzi-Agrò A.. Endocannabinoids and their actions. Vitam Horm 2002; 65: 225-55.
    PubMedGoogle Scholar
  • 5 Kunos G, Járai Z, Batkai S, Goparaju SK, Ishac EJ, Liu J, Wang L, Wagner JA.. Endocannabinoids as cardiovascular modulators. Chem Phys Lipids 2000; 108: 159-68.
    CrossrefPubMedGoogle Scholar
  • 6 Parolaro D, Massi P, Rubino T, Monti E.. Endocannabinoids in the immune system and cancer. Prostaglandins Leukot Essent Fatty Acids 2002; 66: 319-32.
    CrossrefPubMedGoogle Scholar
  • 7 Berdyshev EV, Schmid PC, Krebsbach RJ, Schmid HH.. Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells. FASEB J 2001; 15: 2171-78.
    CrossrefPubMedGoogle Scholar
  • 8 Walker JM, Huang SM.. Endocannabinoids in pain modulation. Prostaglandins Leukot Essent Fatty Acids 2002; 66: 235-42.
    CrossrefPubMedGoogle Scholar
  • 9 Maccarrone M, Del Principe D, Finazzi-Agrò A.. Endocannabinoids: New physiological (co-)agonists of human platelets”. Thromb Haemost 2002; 88: 165-6.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Zygmunt PM, Petersson J, Andersson DA, Chuang H-h, Sorgård M, Di Marzo V, Julius D, Högestätt ED.. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 1999; 400: 452-7.
    CrossrefPubMedGoogle Scholar
  • 11 Járai Z, Wagner J, Varga K, Lake KD.. et al. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci USA 1999; 96: 14136-41.
    CrossrefPubMedGoogle Scholar
  • 12 Liu J, Gao B, Mirshahi F, Sanyal AJ.. et al. Functional CB1 cannabinoid receptors in human vascular endothelial cells. Biochem J 2000; 346: 835-40.
    CrossrefPubMedGoogle Scholar
  • 13 Maccarrone M, Bari M, Lorenzon T, Bisogno T, Di Marzo V, Finazzi-Agrò A.. Anandamide uptake by human endothelial cells and its regulation by nitric oxide. J Biol Chem 2000; 275: 13484-92.
    CrossrefPubMedGoogle Scholar
  • 14 Galve-Roperh I, Sànchez C, Cortes ML, Gómez del Pulgar T, Izquierdo M, Guzman M.. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000; 6: 313-6.
    CrossrefPubMedGoogle Scholar
  • 15 Bifulco M, Laezza C, Portella G, Vitale M, Orlando P, De Petrocellis L, Di Marzo V.. Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. FASEB J 2001; 15: 2745-47.
    CrossrefPubMedGoogle Scholar
  • 16 Guzman M, Sanchez C, Galve-Roperh I.. Cannabinoids and cell fate.. Pharmacol Ther 2002; 95: 175-84.
    CrossrefPubMedGoogle Scholar
  • 17 Gómez del Pulgar T, De Ceballos ML, Guzman M, Velasco G... Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2002; 277: 36527-33.
    CrossrefPubMedGoogle Scholar
  • 18 Yamaji K, Sarker KP, Kawahara K, Iino S, Yamakuchi M, Abeyama K, Hashiguchi T, Maruyama I.. Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications. Thromb Haemost 2003; 89: 875-84.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 19 Wahl GM, Carr AM.. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat Cell Biol 2001; 3: 277-86.
    CrossrefPubMedGoogle Scholar
  • 20 Maccarrone M, Lorenzon T, Bari M, Melino G, Finazzi-Agrò A.. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J Biol Chem 2000; 275: 31938-45.
    CrossrefPubMedGoogle Scholar
  • 21 Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF.. Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science 2002; 298: 1793-96.
    CrossrefPubMedGoogle Scholar
  • 22 Maccarrone M, Bari M, Battista N, FinazziAgrò A.. Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation. Blood 2002; 100: 4040-8.
    CrossrefPubMedGoogle Scholar
  • 23 Bifulco M, Di Marzo V.. Targeting the endocannabinoid system in cancer therapy: a call for further research. Nat Med 2002; 8: 547-50.
    CrossrefPubMedGoogle Scholar
  • 24 Casanova ML, Blazquez C, Martinez-Palacio J.. et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 2003; 111: 43-50.
    CrossrefPubMedGoogle Scholar
  • 25 McKallip RJ, Lombard C, Fisher M.. et al. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 2002; 100: 627-34.
    CrossrefPubMedGoogle Scholar