Thromb Haemost 2003; 89(05): 947-949
DOI: 10.1055/s-0037-1613485
Letters to the Editor
Schattauer GmbH

StabilyteTM tubes that contain strongly acidic citrate prevent in vitrocomplex formation between activated protein C and protein C inhibitor

Karin Strandberg
,
Anita Svensson
,
Johan Stenflo
Further Information

Publication History

Received 21 November 2002

Accepted after revision 24 February 2003

Publication Date:
09 December 2017 (online)

 
  • References

  • 1 Powars D, Larsen R, Johnson J, Hulbert T, Sun T, Patch MJ, Francis R, Chan L.. Epidemic meningococcemia and purpura ftilminans with induced protein C deficiency. Clin Infect Dis 1993; 17: 254-61.
  • 2 Faust S, Levin M, Harrison O, Goldin R, Lockhart M, Kondaveeti S, Laszik Z, Esmon C, Heyderman R.. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med 2001; 345: 408-16.
  • 3 Bernard G, Vincent J-L, Laterre P-F, LaRosa S, Dhainaut J-F, Lopez-Rodrigues A, Stein-grub J, Garber G, Heiterbrand J, Ely W, Fisher C.. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
  • 4 Gruber A, Griffin JH.. Direct detection of activated protein C in blood from human subjects. Blood 1992; 79: 2340-8.
  • 5 España F, Vicente V, Tabernero D, Scharrer I, Griffin JH.. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thromb Res 1990; 59: 593-608.
  • 6 Strandberg K, Kjellberg M, Erb E-M, Persson U, Mosher DF, Villoutreix B, Stenflo J.. Activated protein C-protein C inhibitor complex formation: characterization of a neoepitope provides evidence for extensive insertion of the reactive center loop. Biochemistry 2000; 39: 15713-20.
  • 7 Strandberg K, Kjellberg M, Knebel R, Lilja H, Stenflo J.. A sensitive immunochemical assay for measuring the concentration of the activated protein C-protein C inhibitor complex in plasma: use of a catcher antibody specific for the complexed/cleaved form of the inhibitor. Thromb Haemost 2001; 86: 604-10.
  • 8 Strandberg K, Astermark J, Björgell O, Becker C, Nilsson PE, Stenflo J.. Complexes between activated protein C and protein C inhibitor measured with a new method. Comparison of performance with other markers of hypercoagulability in the diagnosis of deep vein thrombosis. Thromb Haemost 2001; 86: 1400-8.
  • 9 España F, Griffin JH.. Determination of functional and antigenic protein C inhibitor and its complexes with activated protein C in plasma by ELISA's. Thromb Res 1989; 55: 671-82.