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DOI: 10.1055/s-0037-1613575
Formation of platelet microaggregates correlates with adverse clinical outcome in patients with coronary artery disease
Financial support: This study was supported in part by a Research Grant for Cardiovascular Disease (14C-4) from the Ministry of Health and Welfare, a grant-in-aid for scientific research (No. C13670727 and 14770318) from the Ministry of Education, Science, and Culture in Japan and a Smoking Research Foundation Grant for Biomedical Research, Tokyo, Japan.Publication History
Received
16 September 2002
Accepted after revision
10 January 2003
Publication Date:
07 December 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/200304/lookinside/thumbnails/10-1055s-0037-1613575-1.jpg)
Summary
Platelet activation plays a pivotal role in the pathogenesis of acute coronary syndromes. Laser-light scattering in a platelet aggregometer was used to evaluate aggregate size and number quantitatively. Small platelet aggregates ultimately develop into medium and then large platelet aggregates. Thus the measurement of small platelet aggregates is important in the evaluation of thrombus formation.
We examined the relationship between small platelet aggregates and the occurrence of subsequent cardiovascular events. We followed-up 204 patients (149 men and 55 women, mean age 68 ± 9 years) with coronary artery disease (CAD) for 48 months. Blood sampling to determine platelet aggregation was performed on the day of hospital discharge.
The degree of small platelet aggregates [relative risk 4.34, 95% confidence interval (1.62-11.7), p = 0.004] and low left-ventricular ejection fraction [relative risk 2.88, 95% confidence interval (1.23-6.73), p = 0.015] were independent predictors of the occurrence of cardiovascular events in multivariate Cox hazard analysis. In Kaplan-Meier analysis, the degree of small platelet aggregates correlated with the probability of cardiovascular event occurrence.
In patients with CAD, an increase in small platelet aggregates is closely correlated with the future occurrence of cardiovascular events
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