Rapid Change of Platelet Aggregability in Acute Hyperglycemia

Tomohiro Sakamoto; Hisao Ogawa; Hiroaki Kawano; Nobutaka Hirai; Shinzo Miyamoto; Keiji Takazoe; Hirofumi Soejima; Kiyotaka Kugiyama; Michihiro Yoshimura; Hirofumi Yasue

doi:10.1055/s-0037-1613839

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2000; 83(03): 475-479
DOI: 10.1055/s-0037-1613839

Review Article

Schattauer GmbH

Rapid Change of Platelet Aggregability in Acute Hyperglycemia

Detection by a Novel Laser-light Scattering Method

Tomohiro Sakamoto

¹From the Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

,

Hisao Ogawa

¹From the Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

,

Hiroaki Kawano

¹From the Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

,

Nobutaka Hirai

¹From the Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

,

Shinzo Miyamoto

¹From the Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

,

Keiji Takazoe

¹From the Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

,

Hirofumi Soejima

¹From the Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

,

Kiyotaka Kugiyama

¹From the Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

,

Michihiro Yoshimura

¹From the Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

,

Hirofumi Yasue

¹From the Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

› Institutsangaben

Abstract

Summary

We examined the alteration of platelet aggregability in acute hyperglycemia during 75-gram oral glucose tolerance tests (OGTT). Twenty subjects underwent 75-gram OGTT and venous blood samples were obtained before (0 min), 60, 120 and 180 min postload. Platelet aggregability shown as the number of small platelet aggregates was measured with a novel laser-light scattering (LS) method. Platelet aggregability increased in parallel with both glucose and immunoreactive insulin (IRI) levels. The number of mean small aggregates at 60 min (12.30 ± 1.10 × 10⁴) was significantly higher than the one at 0 min (8.32 ± 0.88 × 10⁴, p <0.001), 120 min (10.63 ± 0.98 × 10⁴, p <0.05) and 180 min (8.28 ± 0.84 × 10⁴, p <0.001) (mean ± SEM). Small aggregates correlated positively with plasma glucose levels at 60 min postload (r = 0.67, p = 0.001) while not with IRI. It might be important to suppress transient hyperglycemia for preventing the onset of acute coronary syndromes that could be closely related to platelet hyperaggregability.

Key words

Platelet aggregability - hyperglycemia - glucose tolerance test

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