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Thromb Haemost 2000; 83(03): 517-518
DOI: 10.1055/s-0037-1613852
Letters to the Editor
Schattauer GmbH

Hyperhomocysteinemia, MTHFR C 677T Genotype and Low Folate Levels: A Risk Combination for Acute Coronary Disease in a Portuguese Population

F. Araújo
2   From the Molecular Biology Center, Department of Transfusion Medicine and Blood Bank
,
M. Lopes
2   From the Molecular Biology Center, Department of Transfusion Medicine and Blood Bank
,
L. Gonçalves
2   From the Molecular Biology Center, Department of Transfusion Medicine and Blood Bank
,
M. J. Maciel
1   Cardiology Unit; Hospital S. João, Porto, Portugal
,
L. M. Cunha-Ribeiro
2   From the Molecular Biology Center, Department of Transfusion Medicine and Blood Bank
› Author Affiliations
Further Information

Publication History

Received 27 September 1999

Acepted after revision 15 November 1999

Publication Date:
14 December 2017 (online)

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  • References

  • 1 Araujo F, Santos A, Araujo V, Henriques I, Monteiro F, Meireles E, Moreira I, David D, Maciel MJ, Cunha-Ribeiro LM. Genetic risk factors in acute coronary disease. Haemostasis. 1999 (in press).
    PubMedSearch in Google Scholar
  • 2 Brattstrom L, Wilcken DE, Ohrvik J, Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998; 98: 2520-6.
    CrossrefPubMedSearch in Google Scholar
  • 3 Kluijtmans LAK, Kastelein JJP, Lindermans J, Boers GHJ, Heil SG, Bruschke AVG, Jukema JW, van den Heuvel LPWJ, Trijbels FJM, Boerma GJM, Verheugt FWA, Willems F, Blom HJ. Thermolabile methylenetetrahydrofolate reducatse in coronary artery disease. Circulation 1997; 96: 2573-7.
    CrossrefPubMedSearch in Google Scholar
  • 4 Cattaneo M. Hyperhomocysteinemia, atherosclerosis and thrombosis. Thromb Haemost 1999; 81: 165-76.
    Thieme ConnectPubMedSearch in Google Scholar
  • 5 Arruda VR, von Zuben PM, Chiapani LC, Annichino-Bizzachi JM, Costa FF. The mutation Ala677-Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. Thromb Haemost 1997; 77: 818-21.
    Thieme ConnectPubMedSearch in Google Scholar